The Novel Organic Arsenical Darinaparsin Induces MAPK-Mediated and 2 SHP1-Dependent Cell Death in T-cell Lymphoma and Hodgkin’s Lymphoma
نویسندگان
چکیده
Molecular Oncology Research Institute and Division of Hematology Oncology, Tufts 9 Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, 10 MA, USA; Northwestern University Feinberg School of Medicine, Chicago, IL, USA; 11 Marlene & Stewart Greenebaum Cancer Center, Department of Medicine, University of 12 Maryland, Baltimore, MD, USA; Brigham and Women’s Hospital, Boston, MA, USA; 13 Chemistry of Life Processes Institute, Northwestern University, Evanston, IL and; 14 Robert H. Lurie Cancer Center, Northwestern University, Chicago, IL, USA 15
منابع مشابه
The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models.
PURPOSE Darinaparsin (Zio-101) is a novel organic arsenical compound with encouraging clinical activity in relapsed/refractory T-cell lymphoma (TCL) and Hodgkin lymphoma (HL); however, little is known about its mechanism of action. EXPERIMENTAL DESIGN TCL cell lines (Jurkat, Hut78, and HH) and HL cell lines (L428, L540, and L1236) were examined for in vitro cell death by MTT assay and Annexin...
متن کاملCancer Therapy: Preclinical The Novel Organic Arsenical Darinaparsin Induces MAPK- Mediated and SHP1-Dependent Cell Death in T-cell Lymphoma and Hodgkin Lymphoma Cells and Human Xenograft Models
Purpose: Darinaparsin (Zio-101) is a novel organic arsenical compound with encouraging clinical activity in relapsed/refractory T-cell lymphoma (TCL) and Hodgkin lymphoma (HL); however, little is known about its mechanism of action. Experimental Design: TCL cell lines (Jurkat, Hut78, andHH) andHL cell lines (L428, L540, and L1236) were examined for in vitro cell death by MTT assay and Annexin V...
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